HELPFUL RESOURCES

MedlinePlus: Infectious Diseases

National Institute of Allergy and Infectious Diseases

CDC's Emerging Infectious Diseases

CDC on Healthcare-Associated Infections

CDC Travel and Outbreak Notices

Morbidity and Mortality Weekly Resources

Infectious Diseases: Information from the World Health Organization

JOURNAL SCAN

Behavior Disorder After Encephalitis Caused by Dengue

psychiatryonline.org - 11/30/13

To the Editor: It has been reported that dengue is known as the most frequent human arboviral infection in the world, with 50 million cases per year and 2.5-to-3 million people at risk of contamination, estimated by OMS.¹ Co-circulation of the four types of dengue viruses and expansion of the dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the d

Antidepressant Activity of Linezolid

psychiatryonline.org - 11/30/13

To the Editor: Linezolid is an antibiotic approved for use in cases of infection by highly-resistant bacteria. It has weak activity as an inhibitor of monoamine oxidase.¹ It was reported in 2001 to be associated with a case of serotonin syndrome.² The association of linezolid with serotonin syndrome has been replicated, and it is now accepted pr

The Glucocorticoid Antagonist RU-486 Suppresses HIV Infectivity and Replication

psychiatryonline.org - 11/30/13

The effects of RU-486, a glucocorticoid antagonist, on HIV infection and replication in depressed and nondepressed women were studied using ex vivo models of HIV infection. RU-486 treatment of cells decreased HIV reverse transcriptase activity of monocyte-derived macrophages in a model of acute infectivity. RU-486 also decreased HIV viral replication in the chronically-infected T-cell line ACH-2, but not in the promonocyte cell line U1

Transmission of carcinogenic human papillomavirus types from mother to child: a meta-analysis of published studies

journals.lww.com - 4/30/13

Currently, human papillomavirus (HPV) research focuses on HPV infection in adults and sexual transmission. Data on HPV infection in children are slowly becoming available. It is a matter of debate whether mother-to-child transmission of HP

Usefulness of Intracardiac Echocardiography for the Diagnosis of Cardiovascular Implantable Electronic DeviceRelated Endocarditis

Content.onlinejacc.org - 4/2/13

Objectives

The goal of this study was to compare transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) for the diagnosis of cardiac devicerelated endocarditis (CDI).

Background

The diagnosis of infective endocarditis (IE) was established by using the modified Duke criteria based mainly on echocardiography and blood culture results. No previous studies have compared ICE with TEE for the diagno

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GUIDELINES

Guide to Clinical Preventive Services, 2010-2011: Section 2 (continued)

www.ahrq.gov - 8/31/10

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

Guide to Clinical Preventive Services, 2010-2011: Appendix Table: Recommended Childhood and Adolescent Immunization Schedule

www.ahrq.gov - 8/31/10

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

Guide to Clinical Preventive Services, 2010-2011: Appendix Table: Recommended Immunization Schedule for Persons Aged 7-18 Years

www.ahrq.gov - 8/31/10

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

Guide to Clinical Preventive Services, 2010-2011

www.ahrq.gov - 8/31/10

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

Guide to Clinical Preventive Services, 2010-2011: Appendix Figure 1: Recommended Adult Immunization Schedule, by Vaccine and Age Group

www.ahrq.gov - 8/31/10

Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

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Infections in Medicine Archive »

NEWS

Another Infection Outbreak Tied to a Compounding Pharmacy

MedPage Today - 5/24/13

(MedPage Today) -- SILVER SPRING, Md. -- Seven patients injected with corticosteroids from a Tennessee compounding pharmacy have fallen ill, including at least one case of apparent fungal infection, the FDA said.

CDC: Teen Births at Record Lows

MedPage Today - 5/24/13

(MedPage Today) -- The teen birth rate in the U.S. has fallen to a record low level, and recent declines have been steepest among Hispanic teenagers, the Centers for Disease Control said Thursday.

Flu Surveillance at the Drug Store? (CME/CE)

MedPage Today - 5/24/13

(MedPage Today) -- Your local pharmacy might one day play an important role in tracking disease outbreaks, Canadian researchers reported.

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JOURNALS: NOSOCOMIAL PNEUMONIA

One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial | BMJ

www.bmj.com - 3/19/13

AbstractObjective To evaluate the effect of initial low energy permissive underfeeding (trophic feeding) versus full energy enteral feeding (full feeding) on physical function and secondary outcomes in patients with acute lung injury.Design Prospective longitudinal follow-up evaluation of the NHLBI ARDS Clinical Trials Networks EDEN trialSetting 41hospitals in the United States.Participants 525 patients with acute lung injury.Interventions Randomised assignment to trophic or full feeding fo

First outbreak of nosocomial Legionella infection in term neonates caused by a cold mist ultrasonic humidifier

cid.oxfordjournals.org - 3/19/13

A cold mist humidifier in a nursery caused the first outbreak of nosocomial Legionellosis in term neonates. Legionella pneumophila serogroups 3 and 1 infected 28% of exposed neonates causing severe pneumonia or milder atypical symptoms, conferring a 33% overall mortality.

Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil

wwwnc.cdc.gov - 3/13/13

Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccines effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 224 months of age who had pneumonia from all causes from January 2005 through August 2011. We used data from the National Hospitalization Information System to conduct an interrupted time-series analysis f

PLOS ONE: The Efficacy and Safety of Linezolid and Glycopeptides in the Treatment of Staphylococcus aureus Infections

www.plosone.org - 3/5/13

PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.

Annals of Internal Medicine | NursePatient Ratios as a Patient Safety Strategy: A Systematic Review

annals.org - 3/4/13

0. Search. Email. American College of Physicians. You must be logged in as an individual user to share content. Copyright in the material you requested is held by American College Of Physicians ( unless otherwise noted). This email ability is

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JOURNALS: PEDIATRIC INFECTIONS

Trends in life expectancy in Europe: one big explanation or many small ones?

researchonline.lshtm.ac.uk -

2013). Trends in life expectancy in Europe: one big explanation or many small ones? ... View statistics for Trends in life expectancy in Europe one big explanation or many small ones.

Ragged Fortunes and Swashbuckling Thrillers; Or, Recreating the Victorian in Young Adult Fiction 1985-2011

researcharchive.vuw.ac.nz -

Ragged Fortunes and Swashbuckling Thrillers; Or, Recreating the Victorian in Young Adult Fiction 1985-2011.

James Macandrew of Otago: Slippery Jim or A Leader Staunch and True?

researcharchive.vuw.ac.nz -

James Macandrew of Otago: Slippery Jim or A Leader Staunch and True?

Risk of Fetal Death after Pandemic Influenza Virus Infection or Vaccination.

researchonline.lshtm.ac.uk -

Background During the 2009 influenza A (H1N1) pandemic, pregnant women were at risk for severe influenza illness. This concern was complicated by questions about vaccine safety in pregnant women that were raised by anecdotal reports of fetal deaths after vaccination. Methods We explored the safety of influenza vaccination of pregnant women by linking Norwegian national registries and medical consultation data to determine influenza diagnosis, vaccination status, birth outcomes, and background information

The effectiveness of mobile-health technology-based health behaviour change or disease management interventions for health care consumers: a systematic review.

researchonline.lshtm.ac.uk -

BACKGROUND Mobile technologies could be a powerful media for providing individual level support to health care consumers. We conducted a systematic review to assess the effectiveness of mobile technology interventions delivered to health care consumers. METHODS AND FINDINGS We searched for all controlled trials of mobile technology-based health interventions delivered to health care consumers using MEDLINE, EMBASE, PsycINFO, Global Health, Web of Science, Cochrane Library, UK NHS HTA (Jan 1990-Sept 2010).

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MEDLINE

Risk of fetal death after pandemic influenza virus infection or vaccination.

pubmed.gov - 1/23/13

During the 2009 influenza A (H1N1) pandemic, pregnant women were at risk for severe influenza illness. This concern was complicated by questions about vaccine safety in pregnant women that were raised by anecdotal reports of fetal deaths after vaccination.|We explored the safety of influenza vaccination of pregnant women by linking Norwegian national registries and medical consultation data to determine influenza diagnosis, vaccination status, birth outcomes, and background information for pregnant women before, during, and after the pandemic. We used Cox regression models to estimate hazard ratios for fetal death, with the gestational day as the time metric and vaccination and pandemic exposure as time-dependent exposure variables.|There were 117,347 eligible pregnancies in Norway from 2009 through 2010. Fetal mortality was 4.9 deaths per 1000 births. During the pandemic, 54% of pregnant women in their second or third trimester were vaccinated. Vaccination during pregnancy

Prospects for treatment of latent HIV.

pubmed.gov - 12/31/12

Recent advances in antiretroviral therapy (ART) have drastically improved the quality of life for people with HIV infection. However, owing to the persistence of latent HIV in the presence of therapy, patients must remain on therapy indefinitely. Currently, the solution to the HIV pandemic rests on the prevention of new infections and many decades of ART for the steadily expanding number of people infected worldwide. ART is costly, requires ongoing medical care, and can have side effects, thereby preventing its universal availability. Therefore, to escape the ironic burdens of therapy, efforts have begun to develop treatments for latent HIV infection. Current approaches propose either complete eradication of infection or induction of a state of stringent control over viral replication without ART. This review will discuss these strategies in detail and their potential for clinical development.

Individual and network factors associated with prevalent hepatitis C infection among rural Appalachian injection drug users.

pubmed.gov - 12/31/12

We determined the factors associated with hepatitis C (HCV) infection among rural Appalachian drug users.|This study included 394 injection drug users (IDUs) participating in a study of social networks and infectious disease risk in Appalachian Kentucky. Trained staff conducted HCV, HIV, and herpes simplex-2 virus (HSV-2) testing, and an interviewer-administered questionnaire measured self-reported risk behaviors and sociometric network characteristics.|The prevalence of HCV infection was 54.6% among rural IDUs. Lifetime factors independently associated with HCV infection included HSV-2, injecting for 5 or more years, posttraumatic stress disorder, injection of cocaine, and injection of prescription opioids. Recent (past-6-month) correlates of HCV infection included sharing of syringes (adjusted odds ratio = 2.24; 95% confidence interval = 1.32, 3.82) and greater levels of eigenvector centrality in the drug network.|One factor emerged that was potentially unique to rural IDUs: the

Epidemiology of 2009 pandemic influenza A virus subtype H1N1 among Kenyans aged 2 months to 18 years, 2009-2010.

pubmed.gov - 12/14/12

The US Army Medical Research Unit-Kenya (USAMRU-K) conducts surveillance for influenza-like illness (ILI) in Kenya. We describe the temporal and geographic progression of A(H1N1)pdm09 as it emerged in Kenya and characterize the outpatient population with A(H1N1)pdm09 infection.|We included patients with ILI aged 2 months to 18 years enrolled during June 2009-August 2010. Respiratory specimens were tested by real-time reverse-transcription polymerase chain reaction for influenza virus. Patients with A(H1N1)pdm09 infection were compared to those with seasonal influenza A virus infection and those with ILI who had no virus or a virus other than influenza virus identified (hereafter, "noninfluenza ILI").|Of 4251 patients with ILI, 193 had laboratory-confirmed A(H1N1)pdm09 infection. The first pandemic influenza case detected by USAMRU-K surveillance was in August 2009; peak activity nationwide occurred during October-November 2009. Patients with A(H1N1)pdm09 infection were more likely to

Influenza surveillance among children with pneumonia admitted to a district hospital in coastal Kenya, 2007-2010.

pubmed.gov - 12/14/12

Influenza data gaps in sub-Saharan Africa include incidence, case fatality, seasonal patterns, and associations with prevalent disorders.|Nasopharyngeal samples from children aged <12 years who were admitted to Kilifi District Hospital during 2007-2010 with severe or very severe pneumonia and resided in the local demographic surveillance system were screened for influenza A, B, and C viruses by molecular methods. Outpatient children provided comparative data.|Of 2002 admissions, influenza A virus infection was diagnosed in 3.5% (71), influenza B virus infection, in 0.9% (19); and influenza C virus infection, in 0.8% (11 of 1404 tested). Four patients with influenza died. Among outpatients, 13 of 331 (3.9%) with acute respiratory infection and 1 of 196 without acute respiratory infection were influenza positive. The annual incidence of severe or very severe pneumonia, of influenza (any type), and of influenza A, was 1321, 60, and 43 cases per 100,000 <5 years of age, respectively. Peak

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CLINICAL TRIALS IN INFECTIONS

Modulating the Alveolar Milieu to Enhance Resolution of Fibrotic Lung Injury

pats.atsjournals.org - 7/14/12

Fibrotic lung injury is often attributed to a myriad of factors, including environmental exposure, age, genetic predisposition, epigenetics, coexisting conditions, acute lung injury, and viral infection. No effective therapies, other than lung transplantation, have proven effective against lung fibrosis. Loss of cellular homeostasis mechanisms in alveolar epithelial type I cells and any inability of type II progenitor cells to resist and repair epithelial injury are indicators that impaired response t

Interleukin-15 and Influenza Virus Infection in a Mouse Model of Chronic Obstructive Pulmonary Disease

pats.atsjournals.org - 4/29/12

Pharmacotherapeutic Approaches to Preventing Acute Exacerbations of Chronic Obstructive Pulmonary Disease

pats.atsjournals.org - 8/3/11

The significance of acute exacerbations in chronic obstructive pulmonary disease (AECOPDs) is increasingly appreciated. AECOPDs result in significant morbidity and mortality and are a significant driver of health care costs. Frequent AECOPDs are associated with poor quality of life and more rapid decline in lung function. As such, reducing their frequency or severity is a key paradigm of COPD therapy. Bronchodilators alone and in combination with inhaled corticosteroids are the current standards of ca

Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits

www.clinicaltrials.gov - 11/2/99

Conditions: AcquiredImmunodeficiencySyndrome; Alcoholism; HIVInfection; Neoplasm; Smoking
Intervention:
Sponsor: NationalCancerInstitute(NCI)
Completed - verified July 2004

A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection

www.clinicaltrials.gov - 11/1/99

Condition: HIVInfections
Intervention: Drug:Ampligen
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified August 1991

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FROM PHYSICIANS PRACTICE

Five Steps to Improving Patient Access
Judy Capko, May 21, 2013
Patient access is getting increased attention through reform initiatives. Here are five steps you can take to make sure patients get appropriate access to care in your office.

Growing HIPAA Threat – Ignore Windows XP at Your Own Peril
Marion K. Jenkins, May 21, 2013
Chances are good that you have some major ticking software time bombs lurking in your medical practice's computer environment, namely Windows XP and Server 2003.

Finding Physician Work-Life Balance in the Small Moments
Jennifer Frank, MD, May 21, 2013
At my practice and at home, things are always busy. There's laundry or homework, or a patient with needs.

Three Areas to Reduce Costs at Your Medical Practice
Greg Mertz, May 19, 2013
By taking a hard look at reducing costs for staffing, overhead, and technology at your medical practice, you may see increased physician compensation.

Dos and Don’ts for Starting a Physician Blog
Michael Woo-Ming, MD, May 18, 2013
Starting a physician blog can provide your medical practice with marketing benefits, but it's important to do it right.

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SEARCHMEDICA NEWS

Is There a Future for Edible Vaccines?

October 14, 2011

FEATURED SEARCH: plantibodies

Many experiments have confirmed that plants can make recombinant peptides that act as antigens to induce pronounced immune responses, according to this review. But although the idea is attractive from the point of view of safety and ease of production, regulatory and technical hurdles have slowed progress to date. The regulatory situation has improved, and improvements in production are ready to move from academia to industry, says the author, a biotechnologist with Thomas Jefferson University.

RESULT: Plant biotechnology for production of recombinant pharmaceuticals
Human Vaccines | Jul 8, 2011 (FREE FULL TEXT)

Most often, plant-based vaccines are discussed as a solution for infectious diseases in developing countries. But they could also prove useful for more costly conditions in countries such as the United States, to judge from the following report.

RESULT: Rapid, high-yield production in plants of individualized idiotype vaccines for non-Hodgkin's lymphoma
Annals of Oncology | May 21, 2010 (FREE FULL TEXT)

MANAGE YOUR PRACTICE

Congress Could Ease International Medical Graduate Restrictions

Physicians Practice - 5/24/13

Congress Could Ease International Medical Graduate Restrictions

Blog | May 24, 2013 | Healthcare Careers, Healthcare Reform, Law & Malpractice, Recruitment

By Aubrey Westgate

Research shows the value of international medical graduates practicing in the U.S. and now Congress wants to help increase their numbers.

Healthcare Reform is Changing the Landscape of Medicine

Physicians Practice - 5/24/13

Healthcare Reform is Changing the Landscape of Medicine

Blog | May 24, 2013 | Healthcare Careers, Healthcare Reform, Patients, Physician Compensation

By J. Scott Litton, Jr., MD

Physicians will likely have a hard time embracing future changes under the Affordable Care Act as the current effects are less than desirable already.

Consider Concierge Medicine before Becoming Just another Employee

Physicians Practice - 5/22/13

Consider Concierge Medicine before Becoming Just another Employee

Blog | May 23, 2013 | Employment, Healthcare Careers, Operations, Physician Compensation, Practice Models

By Wayne Lipton

Traditionally, physicians have been self-employed, making their own practice-based decisions, but that is fading. Concierge medicine can help preserve self-employment.

The Perfect Recipe for Medical Practice Transformation

Physicians Practice - 5/23/13

The Perfect Recipe for Medical Practice Transformation

Blog | May 23, 2013 | Healthcare Reform

By James Doulgeris and Nicholas Bonvicino, MD

If you don’t prepare for reimbursement change, pocket change may be all you have left. Here’s the recipe for success.

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