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JOURNAL SCAN
Behavior Disorder After Encephalitis Caused by Dengue
psychiatryonline.org - 11/30/13
To the Editor: It has been reported that dengue is known as the most frequent human arboviral infection in the world, with 50 million cases per year and 2.5-to-3 million people at risk of contamination, estimated by OMS.1 Co-circulation of the four types of dengue viruses and expansion of the dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the d
Antidepressant Activity of Linezolid
psychiatryonline.org - 11/30/13
To the Editor: Linezolid is an antibiotic approved for use in cases of infection by highly-resistant bacteria. It has weak activity as an inhibitor of monoamine oxidase.1 It was reported in 2001 to be associated with a case of serotonin syndrome.2 The association of linezolid with serotonin syndrome has been replicated, and it is now accepted pr
The Glucocorticoid Antagonist RU-486 Suppresses HIV Infectivity and Replication
psychiatryonline.org - 11/30/13
The effects of RU-486, a glucocorticoid antagonist, on HIV infection and replication in depressed and nondepressed women were studied using ex vivo models of HIV infection. RU-486 treatment of cells decreased HIV reverse transcriptase activity of monocyte-derived macrophages in a model of acute infectivity. RU-486 also decreased HIV viral replication in the chronically-infected T-cell line ACH-2, but not in the promonocyte cell line U1
Transmission of carcinogenic human papillomavirus types from mother to child: a meta-analysis of published studies
journals.lww.com - 4/30/13
imageCurrently, human papillomavirus (HPV) research focuses on HPV infection in adults and sexual transmission. Data on HPV infection in children are slowly becoming available. It is a matter of debate whether mother-to-child transmission of HP
Usefulness of Intracardiac Echocardiography for the Diagnosis of Cardiovascular Implantable Electronic DeviceRelated Endocarditis
Content.onlinejacc.org - 4/2/13
Objectives
The goal of this study was to compare transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) for the diagnosis of cardiac devicerelated endocarditis (CDI).
Background
The diagnosis of infective endocarditis (IE) was established by using the modified Duke criteria based mainly on echocardiography and blood culture results. No previous studies have compared ICE with TEE for the diagno

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GUIDELINES
Guide to Clinical Preventive Services, 2010-2011: Section 2 (continued)
www.ahrq.gov - 8/31/10
Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.
Guide to Clinical Preventive Services, 2010-2011: Appendix Table: Recommended Childhood and Adolescent Immunization Schedule
www.ahrq.gov - 8/31/10
Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.
Guide to Clinical Preventive Services, 2010-2011: Appendix Table: Recommended Immunization Schedule for Persons Aged 7-18 Years
www.ahrq.gov - 8/31/10
Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.
Guide to Clinical Preventive Services, 2010-2011
www.ahrq.gov - 8/31/10
Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.
Guide to Clinical Preventive Services, 2010-2011: Appendix Figure 1: Recommended Adult Immunization Schedule, by Vaccine and Age Group
www.ahrq.gov - 8/31/10
Reviews the evidence for and against hundreds of preventive health services, recommending tests, and counseling interventions when evidence exists that it is effective.

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NEWS
MRI May Spot Meningitis from Tainted Steroids (CME/CE)
MedPage Today - 6/18/13
(MedPage Today) -- A screening MRI may provide early warning of spinal or paraspinal meningitis in patients who received contaminated steroid injections, researchers reported.
MMR Booster Safe in Kids with Arthritis (CME/CE)
MedPage Today - 6/18/13
(MedPage Today) -- The live attenuated booster vaccine for measles, mumps, and rubella (MMR) does not worsen disease in children with juvenile idiopathic arthritis, researchers reported.
HIV Care Not Reaching the Young (CME/CE)
MedPage Today - 6/18/13
(MedPage Today) -- Younger age is a barrier to successful HIV care, researchers reported.

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JOURNALS: NOSOCOMIAL PNEUMONIA
One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial | BMJ
www.bmj.com - 3/19/13
AbstractObjective To evaluate the effect of initial low energy permissive underfeeding (trophic feeding) versus full energy enteral feeding (full feeding) on physical function and secondary outcomes in patients with acute lung injury.Design Prospective longitudinal follow-up evaluation of the NHLBI ARDS Clinical Trials Networks EDEN trialSetting 41hospitals in the United States.Participants 525 patients with acute lung injury.Interventions Randomised assignment to trophic or full feeding fo
First outbreak of nosocomial Legionella infection in term neonates caused by a cold mist ultrasonic humidifier
cid.oxfordjournals.org - 3/19/13

A cold mist humidifier in a nursery caused the first outbreak of nosocomial Legionellosis in term neonates. Legionella pneumophila serogroups 3 and 1 infected 28% of exposed neonates causing severe pneumonia or milder atypical symptoms, conferring a 33% overall mortality.

Effect of 10-Valent Pneumococcal Vaccine on Pneumonia among Children, Brazil
wwwnc.cdc.gov - 3/13/13
Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine (PCV10) to its National Immunization Program. To assess the vaccines effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 224 months of age who had pneumonia from all causes from January 2005 through August 2011. We used data from the National Hospitalization Information System to conduct an interrupted time-series analysis f
PLOS ONE: The Efficacy and Safety of Linezolid and Glycopeptides in the Treatment of Staphylococcus aureus Infections
www.plosone.org - 3/5/13
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
Annals of Internal Medicine | NursePatient Ratios as a Patient Safety Strategy: A Systematic Review
annals.org - 3/4/13
0. Search. Email. American College of Physicians. You must be logged in as an individual user to share content. Copyright in the material you requested is held by American College Of Physicians ( unless otherwise noted). This email ability is

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JOURNALS: PEDIATRIC INFECTIONS
Trends in life expectancy in Europe: one big explanation or many small ones?
researchonline.lshtm.ac.uk -
2013). Trends in life expectancy in Europe: one big explanation or many small ones? ... View statistics for Trends in life expectancy in Europe one big explanation or many small ones.
Ragged Fortunes and Swashbuckling Thrillers; Or, Recreating the Victorian in Young Adult Fiction 1985-2011
researcharchive.vuw.ac.nz -
Ragged Fortunes and Swashbuckling Thrillers; Or, Recreating the Victorian in Young Adult Fiction 1985-2011.
James Macandrew of Otago: Slippery Jim or A Leader Staunch and True?
researcharchive.vuw.ac.nz -
James Macandrew of Otago: Slippery Jim or A Leader Staunch and True?
Risk of Fetal Death after Pandemic Influenza Virus Infection or Vaccination.
researchonline.lshtm.ac.uk -
Background During the 2009 influenza A (H1N1) pandemic, pregnant women were at risk for severe influenza illness. This concern was complicated by questions about vaccine safety in pregnant women that were raised by anecdotal reports of fetal deaths after vaccination. Methods We explored the safety of influenza vaccination of pregnant women by linking Norwegian national registries and medical consultation data to determine influenza diagnosis, vaccination status, birth outcomes, and background information
The effectiveness of mobile-health technology-based health behaviour change or disease management interventions for health care consumers: a systematic review.
researchonline.lshtm.ac.uk -
BACKGROUND Mobile technologies could be a powerful media for providing individual level support to health care consumers. We conducted a systematic review to assess the effectiveness of mobile technology interventions delivered to health care consumers. METHODS AND FINDINGS We searched for all controlled trials of mobile technology-based health interventions delivered to health care consumers using MEDLINE, EMBASE, PsycINFO, Global Health, Web of Science, Cochrane Library, UK NHS HTA (Jan 1990-Sept 2010).

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MEDLINE
Prevalence of HIV and sexually transmitted infections and patterns of recent HIV testing among men who have sex with men in Zagreb, Croatia.
pubmed.gov - 11/1/12
To determine the prevalence of HIV and other sexually transmitted infections (STIs) among men who have sex with men (MSM) in Zagreb, Croatia, and assess correlates of testing for HIV in the past 12 months.|The authors carried out a bio-behavioural survey using respondent-driven sampling (RDS) from September 2010 to February 2011. Participants completed a questionnaire and were asked to provide blood, urine, oropharyngeal and rectal swabs for the detection of infections. Data were analysed using RDS Analysis Tool 6.0.1 and STATA V.8.0.|A total of 387 MSM were recruited at the University Hospital for Infectious Diseases. The age range of recruited men was 18-57 years. HIV prevalence was 2.8% (95% CI 1.1% to 5.1%) (3.6%, unadjusted), lower than that found in the first RDS survey carried out in 2006 (4.5%, 95% 2.2% to 7.3%) (4.9%, unadjusted). The seroprevalence of herpes virus type 2 was 5.9% (6.9, unadjusted) and that of syphilis measured by Treponema pallidum haemagglutination assay
High non-specific T lymphocyte response to the adjuvanted H1N1 vaccine in comparison with the H1N1/H3N2/B-Brisbane vaccine without adjuvant.
pubmed.gov - 11/1/12
Shortly after the report of pandemic 2009 influenza A (H1N1), vaccine manufacturers, in conjunction with public agencies, started developing a H1N1 vaccine. In 2009, various approaches were implemented around the globe. The United States and Australia finally approved only non-adjuvanted H1N1 influenza vaccines, whereas Canada and the EU also approved adjuvanted vaccines. In 2010, seasonal influenza vaccine without adjuvant was again widely accepted in both hemispheres. The addition of adjuvant to the vaccine enhances the immunogenity of the vaccine in the presence of a relatively low amount of antigen. However, it might also induce undesirable non-specific immune response. For this reason, we conducted a prospective observational study to monitor T cell absolute count and H1N1-specific immunogenicity after 2009 and 2010 immunization. Fourteen healthy volunteers received the monovalent H1N1 AS03 adjuvanted influenza vaccine (3.5 g of H1N1 and squalene-based adjuvant) in October 2009.
Both influenza hemagglutinin and polymerase acidic genes are important for delayed pandemic 2009 H1N1 virus clearance in the ferret model.
pubmed.gov - 10/24/12
We previously showed that a pandemic virus, A/Tennessee/560/09(H1N1), had the potential to adapt to human bronchial epithelial cells by the acquisition of hemagglutinin (HA) K154Q and polymerase acidic (PA) protein L295P mutations that conferred a more virulent phenotype. To better elucidate the role of each mutations, we generated recombinant viruses carrying single mutations or both mutations concurrently. The replication of all mutant viruses was significantly higher than that of the wild-type A/Tennessee/560/09 virus in human cells. The HA K154Q mutation reduced the receptor binding affinity of A/Tennessee/560/09 virus to 6-Su-6'SLN and biantennary 6'SLN receptors. In ferrets, H1N1 virus with HA K154Q and PA L295P mutations exhibited significantly higher titers in the upper respiratory tract compared to all other viruses 6 days post-infection. Our results suggest that both single mutations HA K154Q and PA L295P are necessary for delayed virus clearance of A/Tennessee/560/09(H1N1)
Neurologic complications of influenza A(H1N1)pdm09: surveillance in 6 pediatric hospitals.
pubmed.gov - 10/1/12
We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza.|Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, for children aged <15 years with laboratory-confirmed pH1N1'09.|A total of 506 children with pH1N1'09 were hospitalized, of whom 49 (9.7%) had neurologic complications; median age 4.8 years (range 0.5-12.6 years) compared with 3.7 years (0.01-14.9 years) in those without complications. Approximately one-half (55.1%) of the children with neurologic complications had preexisting medical conditions, and 42.8% had preexisting neurologic conditions. On presentation, only 36.7% had the triad of cough, fever, and coryza/runny nose, whereas 38.7% had only 1 or no respiratory symptoms. Seizure was the most common neurologic complication (7.5%). Others included encephalitis/encephalopathy (1.4%),
Profiles of neutralizing antibody response in chronically human immunodeficiency virus type 1 clade B'-infected former plasma donors from China naive to antiretroviral therapy.
pubmed.gov - 9/30/12
Broadly neutralizing antibodies (NAbs) such as those generated in chronic human immunodeficiency virus type 1 (HIV-1) infection are considered a key component for an effective HIV-1 vaccine. Here, we measured NAb responses using a panel of 25 Env-pseudotyped viruses, including clade B, C, A, CRF07_BC and CRF01_AE strains, against plasma samples from 103 subjects in a former plasma donor cohort in central China, who were infected with HIV-1 clade B' for at least 10 years and nave to antiretroviral therapy at the time of sampling. We found that 64% of samples (n=66) neutralized at least half of the viruses tested and 2% (n=2) neutralized all of the viruses, while 5% (n=5) neutralized none of the viruses tested. Strikingly, 29% of plasma samples (n=30) neutralized >80% of the viral strains tested, indicating the presence of broadly reactive NAbs in these patients. When the magnitude (geometric mean ID(50) titres, GMTs) or breadth of neutralization

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CLINICAL TRIALS IN INFECTIONS
Modulating the Alveolar Milieu to Enhance Resolution of Fibrotic Lung Injury
pats.atsjournals.org - 7/14/12

Fibrotic lung injury is often attributed to a myriad of factors, including environmental exposure, age, genetic predisposition, epigenetics, coexisting conditions, acute lung injury, and viral infection. No effective therapies, other than lung transplantation, have proven effective against lung fibrosis. Loss of cellular homeostasis mechanisms in alveolar epithelial type I cells and any inability of type II progenitor cells to resist and repair epithelial injury are indicators that impaired response t

Interleukin-15 and Influenza Virus Infection in a Mouse Model of Chronic Obstructive Pulmonary Disease
pats.atsjournals.org - 4/29/12
Pharmacotherapeutic Approaches to Preventing Acute Exacerbations of Chronic Obstructive Pulmonary Disease
pats.atsjournals.org - 8/3/11

The significance of acute exacerbations in chronic obstructive pulmonary disease (AECOPDs) is increasingly appreciated. AECOPDs result in significant morbidity and mortality and are a significant driver of health care costs. Frequent AECOPDs are associated with poor quality of life and more rapid decline in lung function. As such, reducing their frequency or severity is a key paradigm of COPD therapy. Bronchodilators alone and in combination with inhaled corticosteroids are the current standards of ca

Genetic Factors and Interrelationships for Cancer Risk-Related Behaviors and Complex Traits
www.clinicaltrials.gov - 11/2/99
Conditions: AcquiredImmunodeficiencySyndrome; Alcoholism; HIVInfection; Neoplasm; Smoking
Intervention:
Sponsor: NationalCancerInstitute(NCI)
Completed - verified July 2004
A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of Infection
www.clinicaltrials.gov - 11/1/99
Condition: HIVInfections
Intervention: Drug:Ampligen
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified August 1991

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FROM PHYSICIANS PRACTICE
Key Differences between FQHCs and RHCs
Chastity Werner, RHIT, June 13, 2013
FQHCs and RHCs take up a unique niche among physician practices. And that affects compensation and billing.
Improving Care Coordination in Your Practice
Susanne Madden,  June 12, 2013
Practices are feverishly working to control the rising costs of healthcare - effective care coordination can help.
Refunding Overpayments: Two Options for Medical Practices
Ericka L. Adler,  June 12, 2013
Medicare and Medicaid providers must return overpayments once identified. Here are two different refund approaches for practices to consider when necessary.
Four Easy Ways to Boost Patient Time of Service Collections
Aubrey Westgate,  June 12, 2013
Simple ways your medical practice staff can increase the likelihood patients will pay when presenting for appointments.
iPad Alternatives for Mobile Physicians
Marisa Torrieri, June 11, 2013
As more physicians are seeing the merits of media tablets, the market is expanding, too.
 

 


 
COMMENTS


 
SEARCHMEDICA NEWS
April 30, 2013
Co-infections with Respiratory Viruses May Not Worsen Flu Epidemic
Co-infection with a respiratory virus was not associated with worse outcomes among patients infected during the H1N1 influenza A virus pandemic of 2009. Still, a population-based prospective study shows that non-influenza viruses can help to shape a flu outbreak. More »
April 9, 2013
MRSA Infection Rates Shift with the Seasons
Summertime is peak time for methicillin-resistant Staphylococcus aureus infections. Also, a suggested strategy for addressing vancomycin resistance. More »
March 26, 2013
Two Infected Ears Not Necessarily a Sign of Severe Otitis Media
In children, bilateral otitis media appears to be only slightly more severe than unilateral, according to a study whose authors offer advice on how to judge severity. And a systematic review offers guidance on when to use antibiotics. More »
March 14, 2013
Improving on Tools to Detect Serious Pediatric Infections
Adding a urine analysis to a simple clinical tool can significantly improve the likelihood of detecting serious bacterial infections in young febrile children. The best way also involves gut feelings, temperature, and other factors. More »
February 8, 2013
Genome Sequencing Shows MRSA Spread into the Community
The use of whole-genome sequencing for infection control in a special care baby unit is only one example of how DNA sequencing is beginning to improve outbreak control in the real world. More »
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MANAGE YOUR PRACTICE
Vendor Relationships and Your Medical Practice
Physicians Practice - 6/18/13

Vendor Relationships and Your Medical Practice

Pearl | June 18, 2013 | Pearls, Managers Administrators, Operations
By

Vendor relationship management, done with purpose and thoughtfulness, can benefit any medical practice - large or small.

Why the U.S. Healthcare System is not Broken
Physicians Practice - 6/18/13

Why the U.S. Healthcare System is not Broken

Blog | June 18, 2013 | Healthcare Reform
By

It’s not healthcare, it’s sick-care, and it’s not a system, so it can’t be broken.

High Number of Physicians Feel They Lack Financial Planning Info
Physicians Practice - 6/18/13

High Number of Physicians Feel They Lack Financial Planning Info

Blog | June 18, 2013 | Healthcare Careers, Personal Finance
By

A recent report reveals many doctors feel they don’t know enough about personal finances. We're here to help.

A Reminder for Physicians to Strive for Work-Life Balance
Physicians Practice - 6/18/13

A Reminder for Physicians to Strive for Work-Life Balance

Blog | June 18, 2013 | Work/Life Balance
By

A friend who succumbed to pancreatic cancer reminded me, before her passing, how to live life well.

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